The immunomodulatory glycan LNFPIII initiates alternative activation of murine macrophages in vivo

Initiation of the alternative pathway of

Initiation of the alternative pathway of murine complement by immune complexes is dependent on N-glycans in IgG antibodies

✍ Nirmal K. Banda; Allyson K. Wood; Kazue Takahashi; Brandt Levitt; Pauline M. Rud 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 108 KB

## Abstract ## Objective Collagen antibody–induced arthritis in mice exhibits a requirement for amplification by the alternative pathway of complement. Although the alternative pathway is activated by spontaneous hydrolysis, it is not known whether this pathway can also be initiated directly by Ig