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The immunoglobulin heavy-chain gene 3′ enhancers deregulate bcl-2 promoter usage in t(14;18) lymphoma cells

✍ Scribed by Duan, H; Heckman, C A; Boxer, L M

Book ID
110072066
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
179 KB
Volume
26
Category
Article
ISSN
0950-9232

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The t(14;18)(q32;q21) translocation, involving the BCL2 gene and junctional segments (J H ) of the immunoglobulin heavy chain gene (IGH), constitutes the most common chromosomal translocation in non-Hodgkin's lymphoma of B-cell type. Although the breakpoints in BCL2 are largely clustered within the