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The immunobiology of CD154–CD40–TRAF interactions in atherosclerosis

✍ Scribed by David Engel; Tom Seijkens; Marjorie Poggi; Maryam Sanati; Larissa Thevissen; Linda Beckers; Erwin Wijnands; Dirk Lievens; Esther Lutgens


Book ID
116885599
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
276 KB
Volume
21
Category
Article
ISSN
1044-5323

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The CD154 -CD40 interaction is a critical costimulatory pathway modulating the cellular immune response. Moreover, fulminant hepatitis of various etiologies is characterized by a hepatic influx of CD154-expressing T cells and an upregulation of CD40 expression on Kupffer cells and hepatocytes, impli