The immune system during the pre-cancer and the early cancer period. IL-2 production by PBL from post-menopausal women with and without endometrial carcinoma
✍ Scribed by I. Yron; M. Schickler; B. Fisch; H. Pinkas; J. Ovadia; I. P. Witz
- Book ID
- 102869467
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- French
- Weight
- 786 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
We report on alterations in IL-2 production and cell proliferation following FHA stimulation of peripheral blood lymphocytes (PBL) from stage-I endometrial carcinoma (EC) patients, and on mechanisms involved in these alterations. Our study includes 3 groups: EC patients, post-menopausal women at high risk of developing EC, and age-matched healthy women. IL-2 production was markedly lower in most EC patients than in healthy controls. Varying levels of 11-2 were produced by PBL from women in the high-risk group. The proliferative response of PBL to PHA appeared to correlate with levels of IL-2 production. Our results suggest that macrophages are involved, in part, in the modulation of T-cell functions of EC patients.