The immune response to myelin proteolipid protein in the Lewis rat: identification of the immunodominant B cell epitope
โ Scribed by C.A. Gunn; M.K. Richards; C. Linington
- Book ID
- 119107539
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 627 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0165-5728
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Pooled polyclonal rabbit anti-rat myelin and mouse anti-human proteolipid protein (PLP) antisera were screened against a panel of PLP synthetic peptides spanning residues 178-238 of the protein. Cross-reactivity against one determinant defined by PLP,, 219 was particularly prominent in both the anti
Studies from our laboratory have shown that region 69-84 (synthetic peptide S49S) of myelin basic protein (MBP) defines an encephalitogenic sequence for experimental allergic encephalomyelitis (EAE) in Lewis rats. The most potent EAE inducers are the guinea pig MBP (Gp-MBP) and region 69-84, known a