The immune response to Epstein-Barr nuclear antigen: Conformational and structural features of antibody binding to synthetic peptides
β Scribed by Gary Rhodes; Richard Houghten; Joseph P. Taulane; Dennis Carson; John Vaughan
- Book ID
- 119089385
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 801 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0161-5890
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π SIMILAR VOLUMES
The incidence of antibodies to Epstein-Barr nucleair antigen type 2 (EBNA-2) was determined in sera from rheumatoid arthritis (RA) patients and control subjects, by protein immunoblotting. Sixty-eight percent of the RA patients and 48% of the controls possessed anti-EBNA-2 antibodies. The titer of a
## Abstract Studies on the antibody responses to various EpsteinβBarr virus (EBV) antigens have been instrumental in the understanding of the seroepidemiology and diagnosis of this viral infection and the subsequent carrier state. While antibodies to the viral capsid antigen (VCA), early antigen (E
Prior studies have shown that patients with rheumatoid arthritis (RA) have an increased number of circulating Epstein-Barr virus-infected B lymphocytes and elevated titers of antibody to Epstein-Barr nuclear antigen4 (EBNA-I), the major nuclear antigen ex- pressed in latently infected B cells. Howev
Ten synthetic peptides containing 18-22 residues deduced from the amino-acid sequences of the EBV-encoded latentinfection-associated membrane protein (LMP) and the 2 principal nuclear antigens, EBNA-I and EBNA-2, were tested for their ability to induce lymphokine release from sensitized Tcells of EB