The immediate early genes Fos and Egr1 become STAT1 transcriptional targets in the absence of STAT3
β Scribed by Davide Schiavone; Lidia Avalle; Sarah Dewilde; Valeria Poli
- Book ID
- 113622645
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 730 KB
- Volume
- 585
- Category
- Article
- ISSN
- 0014-5793
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The STAT proteins (signal transducers and activators of transcription) are transcription factors mediating cytokine/growth factor signaling, which play important role in controlling cell cycle progression and apoptosis. In many cancer cell lines and tumors (including gliomas) the STAT proteins (in p
## Abstract ## Objective STAT proteins play an important role in cytokine signaling. Some investigators have reported preferential activation of STATβ1, and others have reported preferential activation of STATβ3, in response to endogenous interleukinβ6 (ILβ6), in patients with rheumatoid arthritis