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The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors

✍ Scribed by Trevor N. Stitt; Doreen Drujan; Brian A. Clarke; Frank Panaro; Yekatarina Timofeyva; William O. Kline; Michael Gonzalez; George D. Yancopoulos; David J. Glass


Book ID
117737415
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
360 KB
Volume
14
Category
Article
ISSN
1097-2765

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## Abstract Corticosterone (CORT) is well known to induce neuronal damage in various brain regions including the hippocampus, but the precise mechanism(s) of action underlying these effects has yet to be fully established. Insulin‐like growth factor‐1 (IGF‐1) is a trophic factor promoting cell surv