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The identification of the cinchona alkaloids by optical-crystallographic measurements

โœ Scribed by Edgar T Wherry; Elias Yanovsky


Book ID
104121999
Publisher
Elsevier Science
Year
1918
Tongue
English
Weight
115 KB
Volume
185
Category
Article
ISSN
0016-0032

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The reaction of silylketenes with thiophenol, mediated by cinchona alkaloid catalysts, proceeds to give a-silylthioester products in good chemical yield and with enantiomeric excess values in the range 79-93%. The absolute configuration of one of the thioester products was determined by X-ray diffra