Evidence is accumulating which suggests that the vertebrate Hox homeobox gene family plays an important role in pattern formation, particularly in the specification of regional diversity. In the last year important advances in the understanding of their regulation and function have been provided usi
The identification of new genes: Gene trapping in transgenic mice
โ Scribed by William C Skarnes
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 567 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0958-1669
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Identification of transgenics still requires PCR and genomic Southern blot hybridization of genomic DNA isolated from tail pieces. Furthermore, identification of transgeneโexpressing transgenics (hereafter called โexpressorโ) requires mRNA analyses (RTโPCR and Northern blot hybridizatio
## Abstract The present paper describes the expression of a target fusion gene, WAP/hGH fused to the EGFPโexpressing gene in transgenic mice derived from the transfer of transgenic embryos selected because of their expression of enhanced green fluorescent protein (EGFP). The 6.7โkb fusion gene was
## Abstract Cuxโ1 is a member of a family of homeobox genes structurally related to Drosophila Cut. Mammalian Cut proteins function as transcriptional repressors of genes specifying terminal differentiation in multiple cell lineages. In addition, mammalian Cut proteins serve as cellโcycleโdependent
Ca(v)2.1 (P/Q-type) voltage-gated calcium channels play an important role in neurotransmitter release at many brain synapses and at the neuromuscular junction. Mutations in the CACNA1A gene, encoding the pore forming alpha(1) subunit of Ca(v)2.1 channels, are associated with a wide spectrum of neuro