Uniparental disomy of chromosome 7 (UPD7) is associated with abnormal phenotypic effects because of inappropriate expression of imprinted genes on chromosome 7. Based on the differential methylation of the promoter region of the imprinted PEG1/MEST locus at 7q32, we designed a multiplex methylation
β¦ LIBER β¦
The identification of micronucleated chromosomes: a possible assay for aneuploidy
β Scribed by Thomson, E.J.; Perry, P.E.
- Book ID
- 111858898
- Publisher
- Oxford University Press
- Year
- 1988
- Tongue
- English
- Weight
- 167 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0267-8357
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## Abstract Uniparental disomy (UPD) describes the inheritance of both homologues of a pair of chromosomes from only one parent. During the last two decades, the clinical impact of UPD and associated imprinting disorders, such as PraderβWilli syndrome (PWS) and Angelman syndrome (AS) increasingly h