✦ LIBER ✦

The identification of cyclic nucleotides from living systems using collision-induced dissociation of ions generated by fast atom bombardment mass spectrometry

✍ Scribed by Eric E. Kingston; John H. Beynon; Russell P. Newton

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 711 KB
Volume: 11
Category: Article
ISSN: 1076-5174
DOI: 10.1002/bms.1200110709

No coin nor oath required. For personal study only.

✦ Synopsis

Extracts derived from rat liver and Phaseolus leaves are shown, by collision-induced dissociation of [MH]+ ions

generated by fast atom bombardment mass spectrometry, to contain cytidine 3',5'-cyclic monophosphate and guanosine 3',5'-cyclic monophosphate respectively, and not the 2',3'-cyclic isomers. Interference peaks, expected to be common to all mass-analysed ion kinetic energy spectra of ions generated by the fast atom bombardment process from glycerol-based matrices are identified. It is shown that unequivocal identification of cytidine 3'J'-cyclic monophosphate can be made at the microgram level. Attempts to derive a quantitative procedure based on using different cyclic nucleotides as internal standards were unsuccessful due to the poor solubility of these compounds in the matrix system.

📜 SIMILAR VOLUMES

The differentiation of isomeric biologic

The differentiation of isomeric biological compounds using collision-induced dissociation of ions generated by fast atom bombardment

✍ Eric E. Kingston; John H. Beynon; Russell P. Newton; Joachim G. Liehr 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English

Characterization of iridoids by fast ato

Characterization of iridoids by fast atom bombardment mass spectrometry followed by collision-induced dissociation of [M + Li]+ ions

✍ Madhusudanan, K. P.; Mathad, V. T.; Shefali, ; Raj, K.; Bhaduri, A. P. 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 146 KB 👁 2 views

Fast atom bombardment mass spectra of a series of naturally occurring and synthetically modified iridoid glycosides were studied using lithium cationization and collision-induced dissociation of the resulting [M Y Li] Y ions. Lithium cationization leads to the unambiguous determination of the molecu

Collision-induced dissociation–mass-anal

Collision-induced dissociation–mass-analysed ion kinetic energy (CID–MIKE) analysis of ions generated by fast atom bombardment of isomeric bile salts

✍ Joachim G. Liehr; Eric E. Kingston; John H. Beynon 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 375 KB 👁 2 views

Negative ion fast atom bombardment and c

Negative ion fast atom bombardment and collision-induced dissociation mass spectrometry of the 2-, 3-, 4- and 6-deoxy derivatives from methyl β-D-galactopyranoside and related compounds

✍ Jan W. Dallinga; Danielle M. F. A. Pachen; Jos C. S. Kleinjans; Pavol Kovac 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 521 KB

Analysis of Bile Acids and Bile Alcohols

Analysis of Bile Acids and Bile Alcohols in Urine by Capillary Column Liquid Chromatography–Mass Spectrometry using Fast Atom Bombardment or Electrospray Ionization and Collision-induced Dissociation

✍ Y. Yang; W. J. Griffiths; H. Nazer; J. Sjövall 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 329 KB 👁 2 views

Solid-phase extraction and group separation by anion exchange chromatography were combined with capillary column liquid chromatography-mass spectrometry (LC/MS) to permit a thorough characterization of bile acids and intact conjugates of bile alcohols in human urine. Groups of compounds were separat