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The ICF syndrome, a DNA methyltransferase 3B deficiency and immunodeficiency disease

✍ Scribed by Melanie Ehrlich


Book ID
117792976
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
225 KB
Volume
109
Category
Article
ISSN
1090-2341

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## Abstract To explore the role of DNA methylation in the brain, we examined the expression pattern of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the mouse central nervous system (CNS). By comparing the levels of Dnmt3a and Dnmt3b mRNAs and proteins in the CNS, we showed that Dnmt3b is det