The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease: Cushing’s Syndrome and Beyond

✍ Scribed by Eliza B. Geer (eds.)

• Publisher: Springer International Publishing
• Year: 2017
• Tongue: English
• Leaves: 323
• Edition: 1
• Category: Library

✦ Synopsis

Cushing´s syndrome is a rare disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function, and psychiatric disease, all of which severely reduce quality of life and life expectancy. This book reviews the role of cortisol in the human body, focusing on the effects of excess cortisol due to Cushing’s syndrome as well as the role of the HPA axis in metabolism, inflammation, and neuropsychiatric function. The volume will cover basic mechanistic data, clinical outcomes data, and novel therapies. Also discussed are everything from abnormalities of the HPA axis, to the role of the HPA axis in the development of neuropsychiatric disorders and metabolic disorders, to new definitions of Cushing’s remission and recurrence. The Hypothalamic Pituitary Adrenal Axis in Health and Disease will provide a comprehensive and multi-disciplinary review of the pathophysiology and outcomes of excess cortisol in the human body and brain as well as the role of the HPA axis in other disease states.

✦ Table of Contents

Front Matter....Pages i-vi
Front Matter....Pages 1-1
Glucocorticoid Regulation of Body Composition and Metabolism....Pages 3-26
Glucocorticoid Regulation of Neurocognitive and Neuropsychiatric Function....Pages 27-41
Glucocorticoids: Inflammation and Immunity....Pages 43-63
Front Matter....Pages 65-65
Molecular Pathogenesis of Primary Adrenal Cushing’s Syndrome....Pages 67-92
Pathogenesis and Treatment of Aggressive Corticotroph Pituitary Tumors....Pages 93-110
Neoplastic/Pathological and Nonneoplastic/Physiological Hypercortisolism: Cushing Versus Pseudo-Cushing Syndromes....Pages 111-136
Imaging Strategies for Localization of ACTH-Secreting Tumors....Pages 137-148
Surgical Treatment of Cushing’s Disease....Pages 149-164
Medical Therapies in Cushing’s Syndrome....Pages 165-179
Mild Adrenal Cortisol Excess....Pages 181-197
Long-Term Effects of Prior Cushing’s Syndrome....Pages 199-224
Cushing’s Disease, Refining the Definition of Remission and Recurrence....Pages 225-252
Front Matter....Pages 253-253
Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis Through a Mutated Glucocorticoid Receptor....Pages 255-269
Cortisol Metabolism as a Regulator of the Tissue-Specific Glucocorticoid Action....Pages 271-301
Obesity and Metabolic Syndrome: A Phenotype of Mild Long-Term Hypercortisolism?....Pages 303-313
Back Matter....Pages 315-327

✦ Subjects

Endocrinology;Systems Biology