Abstract
Feeding of a glycine rich diet with sufficient supply of essential amino acids (mixture of casein and gelatine) causes a significant reduction of the serum triglyceride level in rats. To study some aspects of this triglyceride lowering effect the in vivo incorporation of C^14^βlβacetate and C^14^βlβpalmitate into the serum and liver lipids as well as the lipoprotein lipase and the hormone sensitive lipolytic activity of the epididymal adipose tissue in vitro were estimated. After feeding the gelatine containing diet the incorporation of labelled acetate and palmitate into the serum triglycerides was significantly decreased with no change of the incorporation into the liver triglycerides and without detectable accumulation of liver lipids. The decreased serum triglyceride level of the serum corresponded to a decreased lipoprotein lipase activity in the epididymal adipose tissue, whereas the basal and norepinephrine stimulated lipolysis of this tissue was not affected. From these results it is concluded that due to the feeding of a glycine rich diet the triglyceride secretion of the liver is decreased leading to a lower serum triglyceride level.