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The hyperfluidization of mammalian cell membranes acts as a signal to initiate the heat shock protein response

✍ Scribed by Gábor Balogh; Ibolya Horváth; Enikõ Nagy; Zsófia Hoyk; Sándor Benkõ; Olivier Bensaude; László Vígh


Book ID
111310295
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
298 KB
Volume
272
Category
Article
ISSN
1432-1327

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While oxidative stress can induce a heat shock response, the primary signals that initiate activation have not been identified. To identify such signals, HepG2 and V 79 cells were exposed to menadione, a compound that redox-cycles to generate superoxide. The oxidative stress generated by menadione r