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The Hydrogenation of Amides and Ammonium Salts. The Transalkylation of Tertiary Amines

โœ Scribed by Schneider, Henry J.; Adkins, Homer; McElvain, S. M.


Book ID
127370725
Publisher
American Chemical Society
Year
1952
Tongue
English
Weight
527 KB
Volume
74
Category
Article
ISSN
0002-7863

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Selective reduction of secondary amides
โœ Byung H. Lee; Michael F. Clothier ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 89 KB

Secondary amides activated with a Cbz group can be reduced to their corresponding hemiaminals using lithium borohydride. Hydrogenation then removes the Cbz and hydroxyl groups to produce the related amine. Tertiary amides are not affected.