The humanVpreBgene is located on chromosome 22 near a cluster of({ ext{V}}_{lambda _1 } )gene segments
✍ Scribed by Steven R. Bauer; Kay Huebner; Marcia Budarf; Janet Finan; Jan Erikson; Beverly S. Emanuel; Peter C. Nowell; Carlo M. Croce; Fritz Melchers
- Publisher
- Springer-Verlag
- Year
- 1988
- Tongue
- English
- Weight
- 714 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0093-7711
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✦ Synopsis
The chromosomal location of the human VpreB gene was determined by Southern blotting analysis of restriction enzyme-digested DNAs from a panel of 17 mousehuman somatic cell hybrids. The pattern of hybridization of a VpreB-specific probe in conjunction with earlier analysis of several marker genes allowed the following conclusions: 1) VpreB is on human chromosome 22 within band 22qll .2 distal to the bcr-like gene, bcr-2 and proximal to the bcr-like gene, bcr-4.2) VpreB has been localized relative to several constitutional and tumor-specific breakpoints within 22ql 1.2, segregates in hybrids retaining 22q-chromosomes with some but not with all members of the V×l subgroup of the Vx genes, and is amplified with these genes in K562 cells. 3) The order of the loci on chromosome 22 is centromere~bcr-2, VpreB ,