✍ Scribed by William A. Blattner; V. S. Kalyanaraman; Marjorie Robert-Guroff; T. Andrew Lister; David A. G. Galton; Prem S. Sarin; Michael H. Crawford; Daniel Catovsky; Melvin Greaves; Robert C. Gallo
No coin nor oath required. For personal study only.
Type‐C RNA tumor viruses have been implicated in the etiology of naturally occurring leukemias and lymphomas of animals. Human T‐cell leukemia/lymphoma virus (HTLV) is the first human virus of this class consistently identified in association with a specific type of human leukemia/lymphoma. The isolation of HTLV was made possible by the ability to grow mature T‐cells in tissue culture usually with T‐cell growth factor (TCGF). We now report a cluster of adult T‐cell leukemia/lymphoma among Blacks from the Caribbean in which all eight cases are positive for HTLV virus and/or antibody. These patients have disease that appears indistinguishable from Japanese adult T‐cell leukemia/lymphoma which, as we have also reported, is associated with HTLV in over 90% of cases. The finding of HTLV antibodies in some of the normal population in the Caribbean and Japan, and the clustering of a specific form of T‐cell leukemia/lymphoma in these virus‐endemic areas, suggest that HTLV infection may be associated with the occurrence of a distinctive clinico‐pathologic entity.
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## Abstract The immunological relationship of human T‐cell leukemia/lymphoma virus (HTLV) and the virus found in Japanese adult T‐cell leukemia/lymphoma (ATL) was investigated in detail by testing the specific binding of serum antibodies from Japanese ATL patients and normal Japanese donors to the