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The human protein disulphide isomerase family: substrate interactions and functional properties

✍ Scribed by Ellgaard, Lars; Ruddock, Lloyd W.


Book ID
110032665
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
721 KB
Volume
6
Category
Article
ISSN
1469-221X

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## Abstract The de novo methyltransferase‐like protein, DNMT3L, is required for methylation of imprinted genes in germ cells. Although enzymatically inactive, human DNMT3L was shown to act as a general stimulatory factor for de novo methylation by murine Dnmt3a. Several isoforms of DNMT3A and DNMT3