Physical and functional interactions bet
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Zhao-Xia Chen; Jeffrey R. Mann; Chih-Lin Hsieh; Arthur D. Riggs; FrΓ©dΓ©ric ChΓ©din
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Article
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2005
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John Wiley and Sons
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English
β 357 KB
## Abstract The de novo methyltransferaseβlike protein, DNMT3L, is required for methylation of imprinted genes in germ cells. Although enzymatically inactive, human DNMT3L was shown to act as a general stimulatory factor for de novo methylation by murine Dnmt3a. Several isoforms of DNMT3A and DNMT3