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The human MDR3 P-glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice

โœ Scribed by Alexander J. Smith; Johanna L.P.M. Timmermans-Hereijgers; Ben Roelofsen; Karel W.A. Wirtz; Wim J. van Blitterswijk; Jaap J.M. Smit; Alfred H. Schinkel; Piet Borst


Book ID
115929574
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
522 KB
Volume
354
Category
Article
ISSN
0014-5793

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Mice homozygous for a disruption in the Mdr2 gene (Mdr2 (-/-) mice) lack the Mdr2 P-glycoprotein (P-gp) in the canalicular membrane of the hepatocyte and are unable to excrete phosphatidylcholine into the bile. These mice develop a nonsuppurative cholestatic liver disease, presumably caused by the h