Hepatocyte-specific expression of the hu
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Alexander J. Smith; J. Marleen de Vree; Roelof Ottenhoff; Ronald P. Elferink; Al
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Article
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1998
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John Wiley and Sons
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English
โ 524 KB
Mice homozygous for a disruption in the Mdr2 gene (Mdr2 (-/-) mice) lack the Mdr2 P-glycoprotein (P-gp) in the canalicular membrane of the hepatocyte and are unable to excrete phosphatidylcholine into the bile. These mice develop a nonsuppurative cholestatic liver disease, presumably caused by the h