The human immunodeficiency virus reduces network capacity: Acoustic noise effect

✍ Scribed by Dardo Tomasi; Linda Chang; Elisabeth de Castro Caparelli; Frank Telang; Thomas Ernst

• Book ID: 101462536
• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 222 KB
• Volume: 59
• Category: Article
• ISSN: 0364-5134
• DOI: 10.1002/ana.20766

✦ Synopsis

Abstract

Objective

Increased acoustic noise (AN) during working memory leads to increased brain activation in healthy individuals and may have greater impact in human immunodeficiency virus (HIV) patients.

Results

Compared with control subjects, HIV patients showed reduced AN activation and lower neuronal marker N‐acetylaspartate in prefrontal and parietal cortices. Competing use of the working memory network between AN and cognitive load showed lower dynamic range of the hemodynamic responses in prefrontal and parietal cortices in HIV patients.

Interpretation

These findings suggest that reduced reserve capacity of the working memory network in HIV patients and additional stress (eg, AN) might exhaust the impaired network for more demanding tasks. Ann Neurol 2006;59:419–423