The Human Cancer Antigen Mesothelin Is More Efficiently Presented to the Mouse Immune System when Targeted to the DEC-205/CD205 Receptor on Dendritic Cells

Broad T cell immunity to the LcrV virule

Broad T cell immunity to the LcrV virulence protein is induced by targeted delivery to DEC-205/CD205-positive mouse dendritic cells

✍ Yoonkyung Do; Chae Gyu Park; Young-Sun Kang; Sung Ho Park; Rebecca M. Lynch; Hae 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 343 KB

## Abstract There is a need for a more efficient vaccine against the bacterium __Yersinia pestis__, the agent of pneumonic plague. The F1‐LcrV (F1‐V) subunit vaccine in alhydrogel is known to induce humoral immunity. In this study, we utilized DC to investigate cellular immunity. We genetically eng