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The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones

✍ Scribed by Jing Li; Joanna Soroka; Johannes Buchner

Book ID
113486516
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
956 KB
Volume
1823
Category
Article
ISSN
0167-4889

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## Abstract Activation of the Hsp90 chaperone system is a characteristic of cancer cells. The regulation of chaperone activities involves their interaction with cochaperones; therefore we investigated the expression of Hsp70 and Hsp90 and their specific co-chaperones HOP and CHIP in cancer cell lin