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The HLA–B*2709 subtype in a woman with early ankylosing spondylitis

✍ Scribed by Ignazio Olivieri; Salvatore D'Angelo; Enrico Scarano; Vincenzo Santospirito; Angela Padula

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
101 KB
Volume
56
Category
Article
ISSN
0004-3591

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The naturally occurring polymorphism Asp
The naturally occurring polymorphism Asp116 → His116 , differentiating the ankylosing spondylitis-associated HLA-B*2705 from the non-associated HLA-B*2709 subtype, influences peptide-specific CD8 T cell recognition
✍ Maria Teresa Fiorillo; Giulia Greco; Monica Maragno; Ilaria Potolicchio; Andrea 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 155 KB

HLA-B27 molecules are interesting because of their strong association with ankylosing spondylitis (AS) and reactive arthritis (ReA). A pathogenetic role for these molecules has been postulated in presenting a putative "arthritogenic" peptide to CD8 T cells. The HLA-B\*2709 subtype, although differin