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The histone deacetylase inhibitor trichostatin A sensitizes estrogen receptor α-negative breast cancer cells to tamoxifen

✍ Scribed by Jang, Eun Ryoung; Lim, Soo-Jeong; Lee, Eun Sook; Jeong, Gajin; Kim, Tae-You; Bang, Yung-Jue; Lee, Jong-Soo


Book ID
110068395
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
337 KB
Volume
23
Category
Article
ISSN
0950-9232

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Estrogen receptor-negative breast cancer
✍ M. Saeed Sheikh; Zhi-Ming Shao; Jian-Chyi Chen; Arif Hussain; Anton M. Jetten; J 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 968 KB

We and others have shown previously that retinoic acid (RA) selectively inhibits the growth of estrogen receptor (ER)-positive human breast carcinoma (HBC) cells and ER-negative cells are refractory to RA inhibition o f growth. The ER-negative cells inherently express lower levels of RARa and retino