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The hippocampal dentate gyrus is essential for generating contextual memories of fear and drug-induced reward

✍ Scribed by V. Hernández-Rabaza; L. Hontecillas-Prieto; C. Velázquez-Sánchez; A. Ferragud; A. Pérez-Villaba; A. Arcusa; J.A. Barcia; J.L. Trejo; J.J. Canales

Book ID: 116791692
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 665 KB
Volume: 90
Category: Article
ISSN: 1074-7427
DOI: 10.1016/j.nlm.2008.06.008

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Type 1 insulin-like growth factor receptor signaling is essential for the development of the hippocampal formation and dentate gyrus

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## Abstract Type 1 insulin‐like growth factor receptor (IGF1R) signaling in neuronal development was studied in mutant mice with blunted __igf1r__ gene expression in nestin‐expressing neuronal precursors. At birth [postnatal (P) day 0] brain weights were reduced to 37% and 56% of controls in mice h