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The high-risk benign tumor: Evidence from the two-stage skin cancer model and relevance for human cancer

✍ Scribed by Adam Glick; Andrew Ryscavage; Rolando Perez-Lorenzo; Henry Hennings; Stuart Yuspa; Nadine Darwiche

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
132 KB
Volume
46
Category
Article
ISSN
0899-1987

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✦ Synopsis

Abstract

Benign tumors that form following chemical initiation and promotion in the mouse skin can be grouped into two classes. The majority of papillomas do not progress to squamous cell carcinoma (SCC), and these are designated as low‐risk or terminally benign papillomas. In contrast, a much smaller group forms the true precursor to the SCC, and these have a significantly higher frequency and rate of malignant conversion than the bulk of low‐risk papillomas. In standard two‐stage carcinogenesis studies both tumor types are present, but grossly indistinguishable. Here we describe properties and potential origins of high‐risk papillomas and discuss the relevance of this model for certain human cancers with defined premalignant states. © 2007 Wiley‐Liss, Inc.

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