The heterogeneity of serum globulins (invited discussion)

✍ Scribed by Putnam, Frank W.

• Book ID: 102310380
• Publisher: Wiley (John Wiley & Sons)
• Year: 1956
• Tongue: English
• Weight: 206 KB
• Volume: 47
• Category: Article
• ISSN: 0095-9898
• DOI: 10.1002/jcp.1030470404

✦ Synopsis

I n his conclusion, Dr. Haurowitz brought out an important concept that merits further consideration, namely, the microheterogeneity of proteins. Ten years ago, protein chemists were convinced that many proteins had been prepared in a quite homogeneous form as judged by physicochemical criteria. However, Dr. Alberty and others have now shown (by such methods as boundary spreading measurements) that no protein as yet can be considered truly homogeneous. I n regard to chemical structure, Sanger 's brilliant elucidation of the complete structure of insulin provides the, firmest support yet for the concept that proteins are chemical entities with explicity defined sequence and structure. Yet there is new evi-