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The hERG Potassium Channel and Drug Trapping: Insight from Docking Studies with Propafenone Derivatives

✍ Scribed by Khac-Minh Thai; Andreas Windisch; Daniela Stork; Anna Weinzinger; Andrea Schiesaro; Robert H. Guy; Eugen N. Timin; Steffen Hering; Gerhard F. Ecker

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 667 KB
Volume: 5
Category: Article
ISSN: 1860-7179
DOI: 10.1002/cmdc.200900374

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## Abstract The hERG potassium channel has recently been a matter of extensive studies both at experimental and computational levels, because of its possible involvement in the potentially lethal drug‐induced long QT syndrome. In this context, in the absence of an experimentally determined 3D struc