The hemocompatibility of a nitric oxide generating polymer that catalyzes S-nitrosothiol decomposition in an extracorporeal circulation model

The attenuation of platelet and monocyte

The attenuation of platelet and monocyte activation in a rabbit model of extracorporeal circulation by a nitric oxide releasing polymer

✍ Terry C. Major; David O. Brant; Melissa M. Reynolds; Robert H. Bartlett; Mark E. 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 938 KB

Nitric oxide (NO) has been shown to reduce thrombogenicity by decreasing platelet and monocyte activation by the surface glycoprotein, P-selectin and the integrin, CD11b, respectively. In order to prevent platelet and monocyte activation with exposure to an extracorporeal circulation (ECC), a nitric