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The Hematopoietic Transcription Factor AML1 (RUNX1) Is Negatively Regulated by the Cell Cycle Protein Cyclin D3

✍ Scribed by Peterson, L. F.; Boyapati, A.; Ranganathan, V.; Iwama, A.; Tenen, D. G.; Tsai, S.; Zhang, D.-E.

Book ID
115538913
Publisher
American Society for Microbiology
Year
2005
Tongue
English
Weight
743 KB
Volume
25
Category
Article
ISSN
0270-7306

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## Abstract Several proteins with important roles in oncogenesis have been shown to regulate the function of the E2F‐1 transcription factor, which is known to activate the expression of genes required for proliferation and apoptosis. Here we identify the MDMX oncoprotein as an E2F‐1‐binding factor,