The hemangioblast—an elusive cell captured in culture
✍ Scribed by Lorraine Robb; Andrew G. Elefanty
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 68 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
✦ Synopsis
The close temporal and spatial association between blood and endothelial cell development during embryogenesis was first documented almost 100 years ago. In recent years, gene expression studies have further strengthened this link. Now, using cultures of mouse embryonic stem cells, a common progenitor cell that gives rise to both blood cells and vascular endothelial cells, has been identified. (1) The existence of the hemangioblast has been proved, and experiments addressing its unique properties can begin.
📜 SIMILAR VOLUMES
## Abstract We report here a method that allows fast, efficient, and low‐cost screening for gene function in the vascular system of the vertebrate embryo. Through intracardiac delivery of nucleic acids optimally compacted by a specific cationic lipid, we are able to induce in vivo endothelial cell‐