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The helix-loop-helix domain: A common motif for bristles, muscles and sex

✍ Scribed by Joan Garrell; Sonsoles Campuzano

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
732 KB
Volume
13
Category
Article
ISSN
0265-9247

No coin nor oath required. For personal study only.

✦ Synopsis

Three apparently unrelated developmental processesmammalian myogenesis, the choice of neural fate and sex determination in Drnsophilaare controlled by a common mechanism. Most of the genes governing these processes encode transcriptional factors that contain the helix-loop-helix (HLH) motif. This domain mediates the formation of homo-or heterodimers that specifically bind to DNA through a conserved basic region adjacent to the HLH motif. Dimers differ in their affinity for DNA and in their ability to activate transcription from HLH binding-site containing promoters. In addition, the activity of HLH proteins is inhibited by dimerization with another class of HLH proteins that lack a basic domain entirely or have an altered one. These structural properties provide a molecular mechanism to explain the synergistic and antagonistic functional relations among the HLH encoding genes that control several developmental pathways.

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