The Heck reaction in the presence of molecular oxygen

✍ Scribed by Takahiro Hosokawa; Taisuke Kamiike; Shun-Ichi Murahashi; Mamoru Shimada; Toshihiro Sugafuji

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 134 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)02372-9

✦ Synopsis

Palladium-catalyzed reaction of CH 2 C(R)COOMe (R=H or CH 2 OH) with PhI in the presence of NEt 3 under O 2 induces the oxidative dealkylation of NEt 3 , affording either methyl 3-diethylaminopropionate (3) or methyl (Z)-2-benzyl-3-(N,N%diethylamino)propenate (6), in case of R=H or R=CH 2 OH, respectively.