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The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non-small cell lung cancer

โœ Scribed by Brent Graham; Jayne Curry; Tomoko Smyth; Lynsey Fazal; Ruth Feltell; Isobel Harada; Joe Coyle; Brian Williams; Matthias Reule; Hayley Angove; David M. Cross; John Lyons; Nicola G. Wallis; Neil T. Thompson

Book ID
114703165
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
376 KB
Volume
103
Category
Article
ISSN
1347-9032

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Involvement of calcium in the differential induction of heat shock protein 70 by heat shock protein 90 inhibitors, geldanamycin and radicicol, in human non-small cell lung cancer H460 cells
โœ Yuo-Sheng Chang; Lee-Chen Lee; Fang-Chun Sun; Chih-Chung Chao; Hua-Wen Fu; Yiu-K ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 269 KB ๐Ÿ‘ 2 views

Both geldanamycin (GA) and radicicol (RA) are HSP90 binding agents that possess antitumour activities. Although the in vitro data indicated that the inhibitory constant of RA is much bigger than that of GA, the in vivo data on drug efficacy might reveal different results. We have recently shown that