Previous studies have demonstrated the feasibility of implantation of human blood cells or tissues in lethally irradiated mice or rats, radioprotected with SCID mouse bone marrow cells: The Trimera system. In the present study, we describe the development of a mouse Trimera model for human hepatitis
β¦ LIBER β¦
The HBV trimera mouse: a model for human HBV infection and evaluation of anti-viral agents
β Scribed by Ehud Ilan; Ofer Nussbaum; Ido Lubin; Rachel Eren; Ofer Ben-Moshe; Joseph Arazi; Shoshana Berr; Lewis Neville; Daniel Shouval; Orit Nahor; Yair Reisner; Shlomo Dagan; Eithan Galun
- Book ID
- 118568395
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 163 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0168-8278
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## Abstract In chimpanzee hepatitis B virus (HBV) carriers, the molecular mechanism for viral persistence has been examined by analyzing the properties of viral DNA molecules in liver and serum. Two extrachromosomal HBVβDNA molecules migrating on Southern blots at 4.0 kb and 2.3 kb were observed in