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The H1c haplotype of the MAPT locus is associated with autopsy confirmed late onset Alzheimer’s disease

✍ Scribed by Amanda J. Myers; Mona Kaleem; Lauren Marlowe; Alan Pittman; Hon Chung Fung; Jaime Duckworth; Alison Gibson; Chris M. Morris; Rohan de Silva; John A. Hardy

Book ID
118461788
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
56 KB
Volume
1
Category
Article
ISSN
1552-5260

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## Abstract The __MAPT__ gene that encodes Tau is located on chromosome 17q21, in a region, which has evolved to form two major haplotypes, H1 and H2. There is strong evidence that the H1 haplotype, and a sub‐haplotype (H1C), are overrepresented and associated with increased risk for the sporadic t