The GTPase Rap1 controls functional activation of macrophage integrin αMβ2 by LPS and other inflammatory mediators

Rap1 controls activation of the αMβ2 int

Rap1 controls activation of the αMβ2 integrin in a talin-dependent manner

✍ Jenson Lim; Aurélien G. Dupuy; David R. Critchley; Emmanuelle Caron 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 386 KB

The small GTPase Rap1 and the cytoskeletal protein talin regulate binding of C3bi-opsonised red blood cells (RBC) to integrin a M b 2 in phagocytic cells, although the mechanism has not been investigated. Using COS-7 cells transfected with a M b 2 , we show that Rap1 acts on the b 2 and not the a M