The grading of lymphovascular space invasion in endometrial carcinoma

✍ Scribed by Toru Hachisuga; Tsunehisa Kaku; Kouichi Fukuda; Fuyuki Eguchi; Makoto Emoto; Toshiharu Kamura; Tsuyoshi Iwasaka; Tatsuhiko Kawarabayashi; Hajime Sugimori; Mitsuru Mori

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 250 KB
• Volume: 86
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19991115)86:10<2090::aid-cncr29>3.0.co;2-7

✦ Synopsis

BACKGROUND.

This study was conducted to elucidate the prognostic significance of a three-grade system for lymphovascular space invasion (LVSI).

METHODS.

The prognostic significance of the grading of LVSI as compared with other pathologic variables was evaluated in a study of 303 Japanese women with endometrial carcinoma. The criteria for determining the grade of LVSI were as follows: none (no LVSI), mild (a focus of LVSI was recognized around a tumor), and severe (diffuse or multifocal LVSI were recognized around the tumor or in the myometrium regardless of the degree of myometrial invasion). Both univariate and multivariate regression analyses were performed. The effects of different surgical methods and adjuvant therapies on survival were also examined. FIGURE 4. Graph showing survival rates for patients with lymphadenectomy.