The glucose transporter and blood-brain barrier of human brain tumors
β Scribed by Dr Christopher Guerin; John Laterra; Ralph H. Hruban; Henry Brem; Lester R. Drewes; Gary W. Goldstein
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 976 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0364-5134
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π SIMILAR VOLUMES
W e previously demonstrated that brain microvessels have a high density of the erythrocyte-type glucose transporter and suggested this could be used as a marker of cells with "occluding" junctions. Now, we have studied by immunocytochemistry the tissue distribution of the glucose transporter in a va
## Abstract In adult rats, using the singleβpass brain uptake technique with a tritiated water standard, Lβphenylalanine was shown to enter brain across the bloodβbrain barrier (BBB) by both a saturable and diffusionary process. A kinetic analysis of the data revealed Michaelis constant (K~a~) of 0