The glucose-regulated proteins: stress induction and clinical applications
โ Scribed by Amy S Lee
- Book ID
- 114327094
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 175 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0968-0004
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We have characterized the induction of glucose-regulated proteins (GRPs) in Xenopus laevis A6 cells, a kidney epithelial cell line. Exposure of A 6 cells to medium in which 2-deoxyglucose replaced galactose resulted in enhanced synthesis of two proteins at 78 and 98 kd. The 78 kd protein was determi
Chronic anoxia, glucose starvation, low pH, and numerous other conditions induce the glucose-regulated system of stress proteins (CRPs), whose principal members are observed at 78, 94, and 170 kDa. These stresses may be expected to occur during growth in untreated tumors. To examine the possibility