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The genetics of the sixth and seventh components of complement in the dog: Polymorphism, linkage, locus duplication, and silent alleles

✍ Scribed by P. R. Eldridge; M. J. Hobart; P. J. Lachmann


Publisher
Springer
Year
1983
Tongue
English
Weight
389 KB
Volume
21
Category
Article
ISSN
0006-2928

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πŸ“œ SIMILAR VOLUMES


Genetic polymorphism and linkage of the
✍ D. B. Whitehouse πŸ“‚ Article πŸ“… 1984 πŸ› Springer 🌐 English βš– 605 KB

Using polyacrylamide gel isoelectric focusing and standard specific hemolytic detection methods, genetic polymorphisms have been found in the sixth and seventh complement components (C6 and C7) in two laboratory groups of Common marmosets. The C6 locus is highly variable and the products of six alle

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In man the structural genes for the HLA antigens are encoded on the short arm of chromosome 6 and constitute a linkage group with structural genes of the complement components Bf, C2, and C4 (Allen 1974, Fu et al. 1974, Rittner et al. 1975). The gene products of the whole group are characterized by

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The family of an individual was studied who lacks the seventh component of complement in his serum (C7 homozygous deficiency). Both parents are C7 heterozygous-deficient. In this investigation, the following parameters were determined: complement components in functional and immunochemical tests; HL