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The genetics of the E2F family of transcription factors: shared functions and unique roles

✍ Scribed by James DeGregori


Book ID
114222825
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
514 KB
Volume
1602
Category
Article
ISSN
0304-419X

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Several regulators of E2F transcriptional activity, including the retinoblastoma tumor suppressor (Rb) protein, p16 Ink4a , cyclin D1, and cyclin-dependent kinase 4, have been shown to be targets for genetic alterations that underlie the development of human cancers. Deregulation of E2F transcriptio