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The genetic regulation of liver microsomal CYP2E1 activity among strains of the viviparous fish Poeciliopsis

✍ Scribed by Lisa A.E Kaplan; Eileen Fielding; Joseph F Crivello


Book ID
117794157
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
317 KB
Volume
128
Category
Article
ISSN
1532-0456

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Cytochrome P450 2E1 (CYP2E1) is clinically and toxicologically important and exhibits 24-hour periodicity in its activity. In the present study, we investigated whether hepatic nuclear factor-1␣ (HNF-1␣) and clock genes with a striking 24-hour rhythm in mouse liver contributed to the 24-hour regulat