Molecular genetic basis of renal carcino
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Okio Hino; Etsuko Kobayashi; Youko Hirayama; Toshiyuki Kobayashi; Yoshiaki Kubo;
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Article
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1995
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John Wiley and Sons
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English
โ 382 KB
## Abstract We have recently identified on rat chromosome 10q a germline mutation in the tuberous sclerosis gene(__Tsc2__), the gene predisposing to renal carcinoma(a) in the Eker rat. The homozygous mutant condition is lethal at around the 13th day of fetal life. In heterozygotes, RCs invariably d