The genes forCD37, CD53, andR2, all members of a novel gene family, are located on different chromosomes
✍ Scribed by Kimmo I. Virtaneva; Pavla Angelisová; Thomas Baumruker; Václav Hořejší; Heli Nevanlinna; Jim Schröder
- Publisher
- Springer-Verlag
- Year
- 1993
- Tongue
- English
- Weight
- 524 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0093-7711
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✦ Synopsis
CD37, CD53, and R2 leukocyte surface antigens are members of a novel family of structurally related proteins. They all have four transmembrane-spanning domains with a single major extracellular loop. The CD37 is expressed on B cells and on a subpopulation of T cells. The CD53 is known as a panleukocyte marker. The R2 protein is an activation antigen of T cells. The CD37, CD53, and R2 genes were assigned with the help of human/rodent somatic cell hybrids and human-specific probes to human chromosomes 19, 1, and 11, respectively. For the regional assignment, various deletion hybrids were used to map CD37 to 19p13-q13.4, CD53 to 1p12-p31, and R2 to 11p12.