The generation of L-arginine in endothelial cells is linked to the release of endothelium-derived relaxing factor
β Scribed by Jane A. Mitchell; Markus Hecker; John R. Vane
- Book ID
- 115883429
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 146 KB
- Volume
- 176
- Category
- Article
- ISSN
- 0014-2999
No coin nor oath required. For personal study only.
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## Abstract To determine whether endotheliumβderived relaxing factor (EDRF) contributes to the regulation of endothelial permeability, the transendothelial flux of ^14^Cβsuβcrose, a marker for the paracellular pathway across endothelial monolayers (Oliver, __J. Cell. Physiol.__ 145:536β548, 1990),
The effects of a recently described inhibitor of endothelial NO synthesis, NG-nitro-L-arginine (L-NNA), on the vasomotor responses to endothelium-dependent and independent vasodilators, and on the release of endothelium-derived relaxing factor (EDRF), were studied in the isolated saline-perfused rab