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The generation and characterisation of antagonist RNA aptamers to MCP-1

✍ Scribed by Andrew Rhodes; Nick Smithers; Trevor Chapman; Sarah Parsons; Stephen Rees

Book ID
117103420
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
313 KB
Volume
506
Category
Article
ISSN
0014-5793

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G-protein-coupled receptors (GPCRs) are integral membrane proteins involved in signal transduction and constitute major drug targets for disease therapy. Aptamers, which are globular RNA or DNA molecules evolved to specifically bind a target, could represent a valuable tool with which to probe the r