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The general stochastic model of nucleotide substitution

✍ Scribed by F. Rodríguez; J.L. Oliver; A. Marín; J.R. Medina

Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
715 KB
Volume
142
Category
Article
ISSN
0022-5193

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✦ Synopsis

DNA sequence evolution through nucleotide substitution may be assimilated to a stationary Markov process. The fundamental equations of the general model, with 12 independent substitution parameters, are used to obtain a formula which corrects the effect of multiple and parallel substitutions on the measure of evolutionary divergence between two homologous sequences. We show that only reversible models, with six independent parameters, allow the calculation of the substitution rates. Simulation experiments on DNA sequence evolution through nucleotide substitution call into question the effectiveness of the general model (and of any other more detailed description); nevertheless, the general model results are slightly superior to any of its particular cases.

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